Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma.

Alexander BeckFranziska TrippelAlexandra WagnerSaskia JoppienMax FelleChristian VokuhlThomas SchwarzmayrTim M StromDietrich von SchweinitzGernot LängstRoland Kappler

Published in: Clinical epigenetics (2018)

These findings suggest that UHRF1 is critical for aberrant TSG silencing and sustained growth signaling in HB and that UHRF1 overexpression levels might serve as a prognostic biomarker and potential molecular target for HB patients.

Keyphrases

end stage renal disease
cell proliferation
newly diagnosed
chronic kidney disease
ejection fraction
peritoneal dialysis
prognostic factors
genome wide
gene expression
dna methylation
single molecule
genome wide identification