Prolongation of rat-to-mouse islets xenograft survival by co-transplantation of autologous IL-10 differentiated murine tolerogenic dendritic cells.

Natacha MadelonElisa MontanariLyssia GruazJoel PimentaYannick D Muller Leo H Bühler Gisella L Puga Yung Jörg Dieter Seebach

Published in: Xenotransplantation (2020)

Autologous IL-10-differentiated DC with tolerogenic properties prolong rat-to-mouse islets xenograft survival, potentially by locally inducing immune regulatory cells, indicating their potential for regulatory immune cell therapy in xenotransplantation.

Keyphrases

dendritic cells
cell therapy
regulatory t cells
stem cells
mesenchymal stem cells
immune response
induced apoptosis
oxidative stress
transcription factor
free survival
cell cycle arrest
endoplasmic reticulum stress
cell proliferation