PRO-C3 and ADAPT algorithm accurately identify patients with advanced fibrosis due to alcohol-related liver disease.

Bjørn Staehr MadsenMaja ThieleSönke DetlefsenMaria KjaergaardLinda S MøllerJonel TrebickaMette J NielsenNatasja Staehr GudmannDiana J LeemingMorten A KarsdalAleksander Kragnull null

Published in: Alimentary pharmacology & therapeutics (2021)

PRO-C3 is a new marker with high accuracy to detect advanced alcohol-related liver fibrosis. The diagnostic accuracy of PRO-C3 can be further improved by using the ADAPT algorithm in which the test outperforms currently available non-patented serological fibrosis markers. The study is registered in the Odense Patient Data Exploratory Network (OPEN) under study identification numbers OP_040 (https://open.rsyd.dk/OpenProjects/da/openProject.jsp?openNo=40) and OP_239 (https://open.rsyd.dk/OpenProjects/openProject.jsp?openNo=239&lang=da).

Keyphrases

liver fibrosis
minimally invasive
machine learning
electronic health record
alcohol consumption
big data
neural network