Association of Adiponectin and Vitamin D With Tumor Infiltrating Lymphocytes and Survival in Stage III Colon Cancer.
Frank A SinicropeQian ShiThomas C SmyrkRichard M GoldbergSteven J CohenSharlene GillMorton S KahlenbergSuresh G NairAnthony F ShieldBalkrishna N JahagirdarSawyer B JacobsonNathan R FosterMichael N PollakSteven R AlbertsPublished in: JNCI cancer spectrum (2021)
Lower circulating adiponectin levels were associated with a statistically significant increase in TIL densities in colon cancers, indicating an enhanced antitumor immune response. In contrast to TILs, neither adiponectin nor 25(OH)D was independently prognostic.