Evaluation of the Rho-kinase gene expression and polymorphisms in adult patients with acute appendicitis: a differential impact of gender.

Nahide Ekici Günay Emre Bulbul Elif Funda Sener Reyhan Tahtasakal Demiryürek Şeniz Nurullah Günay Demiryürek Tuncay Abdullah

Published in: Revista da Associacao Medica Brasileira (1992) (2022)

Our data imply that Rho-kinase1 (rs35996865) and Rho-kinase2 (rs2230774) gene variants are not risk factors for the development of acute appendicitis in the Turkish population. However, increased mRNA expression of the Rho-kinase1 gene in males indicated that Rho-kinase1 is involved in the pathogenesis of acute appendicitis in a gender-specific way.

Keyphrases

protein kinase
gene expression
tyrosine kinase
genome wide
dna methylation
machine learning
deep learning