Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults.

Tomoko WatanabeTakayuki HondaHirohiko TotsukaMasayuki YoshidaMaki TaniokaKouya ShiraishiYoko ShimadaEri AraiMineko UshiamaKenji TamuraTeruhiko YoshidaYae KanaiTakashi Kohno

Published in: Breast cancer research and treatment (2020)

The HRD-high phenotype of AYA breast cancer patients can be deduced from genomic and pathological factors that are routinely examined in the oncology clinic, irrespective of germline BRCA1/2 mutations.

Keyphrases

dna repair
dna damage
palliative care
primary care
copy number
replacement therapy
gene expression
oxidative stress
breast cancer risk
dna methylation