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Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature.

Benjamin I LauferJ Antonio GomezJulia M JianuJanine M LaSalle
Published in: Epigenetics & chromatin (2021)
Taken together, these results support a mechanism whereby regions of bivalent chromatin that lose H3K4me3 during neuronal differentiation are targeted by excess DNMT3L and become hypermethylated. Overall, these findings demonstrate that DNMT3L overexpression during neurodevelopment recreates a facet of the genome-wide DS DNA methylation signature by targeting known genes and gene clusters that display pan-tissue differential methylation in DS.
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • gene expression
  • cell proliferation
  • transcription factor
  • spinal cord
  • cancer therapy
  • oxidative stress