Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases.
Melina LopezPedro F MalacarneAnna Gajos-DrausXinxin DingAndreas DaiberJon O LundbergStefan OffermannsRalf P BrandesFlávia RezendePublished in: British journal of pharmacology (2021)
Our data suggest that metabolism by vascular CYPs does not contribute to the pharmacological function of organic nitrates.