Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: A cross-sectional diffusion tensor imaging study.
Lize C JiskootMartina BocchettaJennifer M NicholasDavid M CashDavid ThomasMarc ModatSebastien OurselinSerge A R B RomboutsElise G P DopperLieke H MeeterJessica L PanmanRick van MinkelenEmma L van der EndeLaura Donker KaatYolande A L PijnenburgBarbara BorroniDaniela GalimbertiMario MasellisMaria Carmela TartagliaJames RoweCaroline GraffFabrizio TagliaviniGiovanni B FrisoniRobert LaforceElizabeth FingerAlexandre de MendonçaSandro Sorbinull nullJanne M PapmaJohn C van SwietenJonathan D RohrerPublished in: Annals of clinical and translational neurology (2018)
This study demonstrates the presence of early and widespread WM integrity loss in presymptomatic FTD, and suggests a clear genotypic "fingerprint." Our findings corroborate the notion of FTD as a network-based disease, where changes in connectivity are some of the earliest detectable features, and identify diffusion tensor imaging as a potential neuroimaging biomarker for disease-tracking and -staging in presymptomatic to early-stage familial FTD.