Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection.
Christian SelingerMassilva RahmounCarmen Lia MurallClaire BernatVanina BouéMarine BonneauChristelle GrafSophie GrassetSoraya GrocJacques ReynesChristophe HirtzNathalie JacobsSamuel AlizonPublished in: Immunologic research (2021)
Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346.