Beyond RCTs: Short-term dual antiplatelet therapy in secondary prevention of ischemic stroke and transient ischemic attack.
Eleonora De MatteisRaffaele OrnelloFederico De SantisMatteo FoschiMichele RomoliTiziana TassinariValentina SaiaSilvia CenciarelliChiara BedettiChiara PadiglioniBruno CensoriValentina PuglisiLuisa VinciguerraMaria GuarinoValentina BaroneMarialuisa ZeddeIlaria GrisendiMarina DiomediMaria Rosaria BagnatoMarco PetruzzellisDomenico Maria MezzapesaPietro Di ViestiVincenzo InchingoloManuel CappellariMara ZenoriniPaolo CandelaresiVincenzo AndreoneGiuseppe RinaldiAlessandra BavaroAnna CavalliniStefan MoraruPietro QuerzaniValeria TerrusoMarina ManninoAlessandro PezziniGiovanni FrisulloFrancesco MusciaMaurizio PaciaroniMaria Giulia MosconiAndrea ZiniRuggiero LeoneCarmela PalmieriLetizia Maria CupiniMichela MarconRossana TassiEnzo SanzaroCristina PaciGiovanna ViticchiDaniele OrsucciAnne FalcouSusanna DiamantiRoberto TarlettiPatrizia NenciniEugenia RotaFederica Nicoletta SepeDelfina FerrandiLuigi CaputiGino VolpiSalvatore La SpadaMario BecciaClaudia RinaldiVincenzo MastrangeloFrancesco Di BlasioPaolo InvernizziGiuseppe PelliccioniMaria Vittoria De AngelisLaura BonanniGiampietro RuzzaEmanuele Alessandro CaggiaMonia RussoAgnese TononMaria Cristina AcciarriSabrina AnticoliCinzia RobertiGiovanni ManobiancaGaspare ScaglioneFrancesca PistoiaAlberto FortiniAntonella De BoniAlessandra SannaAlberto ChitiLeonardo BarbariniMarcella CaggiulaMaela MasatoMassimo Del SetteFrancesco PassarelliMaria Roberta BongioanniDanilo ToniStefano RicciSimona SaccoPublished in: European stroke journal (2024)
In real-world, most of the patients who receive DAPT after an ischemic stroke or a TIA do not follow RCTs entry criteria and procedures. Nevertheless, short-term DAPT remains effective and safe in this population. No safety concerns are raised in patients with low-risk TIA, more severe stroke, and delayed treatment start.