Ras isoforms: signaling specificities in CD40 pathway.

Arathi NairSushmita ChakrabortyLate Anirban BanerjiAnkita SrivastavaCharudutta NavareBhaskar Saha

Published in: Cell communication and signaling : CCS (2020)

The activator and effector specificities of Ras isoforms in CD40 signaling indicated their differential involvement in CD40 pathway and in maintaining the reciprocity. Our observations reveal Ras-regulated signaling outcome and its potential for developing Ras isoform-targeted immunotherapy and prophylaxis.

Keyphrases

wild type
transcription factor
cancer therapy
single cell
regulatory t cells
genome wide
toll like receptor
inflammatory response