The association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci.

Bartłomiej KisielKatarzyna KisielKonrad SzymańskiWojciech MackiewiczEwelina Biało-WójcickaSebastian UczniakAnna FogtmanRoksana Iwanicka-NowickaMarta KoblowskaHelena KossowskaGrzegorz PlachaMaciej SykulskiArtur BachtaWitold TłustochowiczRafał PłoskiAndrzej Kaszuba

Published in: PloS one (2017)

We confirmed the association of Ps with several previously identified genetic risk factors in a Polish population. We found that a GRS combining 16 SNPs at least nominally associated with Ps had a significantly better discriminatory ability than HLA-C or GRS combining SNPs associated with Ps after the Bonferroni correction. In contrast, adding additional SNPs to GRS did not increase significantly the discriminative power.

Keyphrases

genome wide
dna methylation
risk factors
genome wide association
copy number
magnetic resonance
contrast enhanced