Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1).

Francesco CiconeThibaut DenoëlSilvano GnesinNicolo RiggiMelita IrvingGopinadh JakkaNiklaus SchaeferDavid ViertlGeorge CoukosJohn O Prior

Published in: Molecular imaging and biology (2021)

[111In]CHX-DTPA-scFv78-Fc binds specifically to endosialin/TEM1 in vitro and in vivo. Dosimetry estimates are in the range of other monoclonal antibodies radiolabeled with indium-111. [111In]CHX-DTPA-scFv78-Fc could be potentially translated into clinic.

Keyphrases

primary care
endothelial cells
monte carlo
cancer therapy
cell therapy
mesenchymal stem cells
drug delivery
clinical evaluation