Asymmetric synthesis of quaternary α-trifluoromethyl α-amino acids by Ir-catalyzed allylation followed by kinetic resolution.
Xi-Shang SunQiu Ou-YangShi-Ming XuXing-Heng WangHai-Yan TaoLung-Wa ChungChun-Jiang WangPublished in: Chemical communications (Cambridge, England) (2020)
Facile access to quaternary α-trifluoromethyl α-amino acids has been developed. This sequential reaction involves an Ir-catalyzed asymmetric allylation of α-trifluoromethyl aldimine esters followed by an unprecedented kinetic resolution.