Transcription Factor IRF4 Dysfunction Affects the Immunosuppressive Function of Treg Cells in Patients with Primary Immune Thrombocytopenia.

Meiwen TangLuya ChengFeng LiBoting WuPu ChenYanxia ZhanFanli HuaZhihui MinYang KeChanjuan LiuLing YuanLihua SunHao Chen Lili Ji Yunfeng Cheng

Published in: BioMed research international (2019)

The skewed ratio of Th17/Treg cells and dysfunction of Treg cells in newly diagnosed ITP patients was at least partly caused by IRF4 dysfunction. The underlying mechanism might be the impact of IRF4 on the metabolism of Treg and Teff cells.

Keyphrases

induced apoptosis
newly diagnosed
cell cycle arrest
oxidative stress
transcription factor
endoplasmic reticulum stress
dendritic cells
immune response
patient reported outcomes