Association of MBL-2 gene polymorphisms with systemic lupus erythematosus: an updated meta-analysis and trial sequential analysis.

Harishankar MahtoAbhijit PatiSushil K SahuHanuman Prasad SharmaArchana PadhiAditya Kumar Panda

Published in: Lupus (2020)

MBL-2 variants (A > O and A > B) are associated with predisposition to SLE. Conversely, promoter polymorphism (Y-221X) offers protection against SLE development.

Keyphrases

systemic lupus erythematosus
disease activity
systematic review
dna methylation
study protocol
clinical trial
meta analyses
gene expression
transcription factor
copy number
phase iii
rheumatoid arthritis
case control
open label
genome wide