Long-term brain status and cognitive impairment in children treated for high-risk acute lymphoblastic leukemia with and without allogeneic hematopoietic stem cell transplantation: A single-center study.
Olga Zajac-SpychalaMikolaj A PawlakKatarzyna Karmelita-KatulskaJakub PilarczykKatarzyna Jończyk-PotocznaAgnieszka PrzepióraKatarzyna DerwichAnna PieczonkaJacek WachowiakPublished in: Pediatric blood & cancer (2020)
In pediatric patients treated for ALL, FTBI-based preparative regimen preceding allo-HSCT causes reduction of subcortical structure volumes and decline in cognitive performance. The observed long-term structural and functional CNS sequelae are significantly more pronounced in transplanted HR-ALL patients than in those treated with prophylactic CNS- radiotherapy only.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- acute lymphoblastic leukemia
- newly diagnosed
- cognitive impairment
- end stage renal disease
- acute myeloid leukemia
- white matter
- ejection fraction
- blood brain barrier
- young adults
- prognostic factors
- radiation therapy
- peritoneal dialysis
- squamous cell carcinoma
- multiple sclerosis
- patient reported outcomes
- locally advanced
- brain injury
- subarachnoid hemorrhage
- patient reported
- rectal cancer