Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice.
Katharina E MeijboomEmma R SuttonEve McCallionEmily McFallDaniel AnthonyBenjamin EdwardsSabrina KubinskiInes TapkenInes BünermannGareth HazellNina AhlskogPeter ClausKay E DaviesRashmi KotharyMatthew J A WoodMelissa BowermanPublished in: Skeletal muscle (2022)
Our study provides mechanistic insights into potential molecular players that contribute to muscle pathology in SMA and into likely differential responses of the TWEAK/Fn14 pathway in developing muscle.