Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products.
Clémentine MirabelEduard Puente-MassaguerAnna Del Mazo-BarbaraBlanca ReyesPhilip MortonFrancesc GòdiaJoaquim VivesPublished in: Journal of translational medicine (2018)
The use of optimal formulations for each cell type of interest is crucial to extend the shelf life of cell-based pharmaceuticals and contribute to solve logistical challenges. We demonstrated that the use of Plasmalyte 148 supplemented with 2% (w/v) AlbIX resulted in superior stability of multipotent mesenchymal stromal cells without affecting their identity and multipotency.