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Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products.

Clémentine MirabelEduard Puente-MassaguerAnna Del Mazo-BarbaraBlanca ReyesPhilip MortonFrancesc GòdiaJoaquim Vives
Published in: Journal of translational medicine (2018)
The use of optimal formulations for each cell type of interest is crucial to extend the shelf life of cell-based pharmaceuticals and contribute to solve logistical challenges. We demonstrated that the use of Plasmalyte 148 supplemented with 2% (w/v) AlbIX resulted in superior stability of multipotent mesenchymal stromal cells without affecting their identity and multipotency.
Keyphrases
  • bone marrow
  • single cell
  • cell therapy
  • mesenchymal stem cells