DNA Methylation and mRNA Expression of B7-H3 Gene in Ankylosing Spondylitis: A Case-Control Study.

Yuting ChenYe WuHui YangJinian WangJiangping KongLingxiang YuMan NiYujie DengSheng-Qian XuHaiyang YuZongwen ShuaiFa-Ming Pan

Published in: Immunological investigations (2022)

Epigenetic modifications of B7-H3 were associated with susceptibility to AS. Hypomethylation of the B7-H3 promoter, which leads to B7-H3 overexpression, may be involved in the pathogenesis of AS.

Keyphrases

dna methylation
ankylosing spondylitis
genome wide
copy number
gene expression
disease activity
rheumatoid arthritis
cell proliferation
transcription factor
genome wide identification
systemic lupus erythematosus