IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM.
Markella ZannikouJoseph T DuffyRebecca N LevineMaggie SeblaniQianli LiuAaron PresserVictor A ArrietaChristopher J ChenAdam M SonabendCraig M HorbinskiCatalina Lee-ChangJason MiskaMaciej S LesniakStephen GottschalkIrina V BalyasnikovaPublished in: Journal for immunotherapy of cancer (2023)
We demonstrate that MDSC of the glioma TME express IL15Ra and that these cells can be targeted with secretory IL15 or an IL15Rα-targeting moiety incorporated into the CAR. Thus, IL15-modified CAR T cells act as a dual targeting agent against tumor cells and MDSC in GBM, warranting their future evaluation in early-phase clinical studies.