Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue.

James J M Loan Caoimhe KirbyKatherine EmelianovaOwen R Dando Michael Tin-Chung PoonLeisan PimenovaGiles E Hardingham Barry W McColl Catharina J M Klijn Rustam Al-Shahi Salman Floris H B M Schreuder Catharina J M Klijn

Published in: Journal of neurology, neurosurgery, and psychiatry (2021)

Interleukin-1β abundance is increased after ICH, but analyses of other inflammatory molecules after ICH lack replication. Interleukin-1β pathway modulators may optimise inflammatory responses to ICH and merit testing in clinical trials.

Keyphrases

clinical trial
oxidative stress
small molecule
resting state
case report
white matter
functional connectivity
antibiotic resistance genes
single molecule
multiple sclerosis
cerebral ischemia
study protocol
phase iii
subarachnoid hemorrhage