Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation.

Shengnan ChenBo LiLei ChenHongli Jiang

Published in: Journal of translational medicine (2023)

RES may target PPARA, SHBG, AKR1B1, PPARG, IGF1R, MMP9, AKT1, and INSR domains to act as a therapeutic agent for DKD. These findings comprehensively reveal the potential therapeutic targets for RES against DKD and provide theoretical bases for the clinical application of RES in the treatment of DKD.

Keyphrases

molecular docking
type diabetes
molecular dynamics simulations
signaling pathway
gene expression
binding protein
combination therapy
risk assessment
replacement therapy
cell migration