Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block.

Michelangelo PaciJ HyttinenB RodriguezS Severi

Published in: British journal of pharmacology (2015)

In silico hiPSC-CMs and hAdultV-CMs exhibit a similar response to selective current blocks. However, overall hiPSC-CMs show greater sensitivity to block, which may facilitate in vitro identification of drug-induced effects. Extrapolation of drug effects from hiPSC-CM to hAdultV-CM and pro-arrhythmic risk assessment can be facilitated by in silico predictions using biophysically-based computational models.

Keyphrases

drug induced
liver injury
molecular docking
risk assessment
endothelial cells
high glucose
emergency department
adverse drug
heavy metals
oxidative stress
induced pluripotent stem cells
young adults
climate change
molecular dynamics simulations
bioinformatics analysis