To establish a model for the prediction of initial standard and maintenance doses of warfarin for the Han Chinese population based on gene polymorphism: a multicenter study.

Xiaotong XiaNianxu HuangBoxia LiYan LiLang ZouDongdong YuanBanghua HuangYufei BeiYuxin LiuJinglan FuTingting WuWenjun ChenShaojun JiangMeina LvJin-Hua Zhang

Published in: European journal of clinical pharmacology (2021)

The genetic and non-genetic factors affecting warfarin dose in Chinese Han population were studied systematically in this study. The pharmacogenomic dose prediction model constructed in this study can predict anticoagulant efficacy of warfarin and has potential application value in clinical practice.

Keyphrases

atrial fibrillation
venous thromboembolism
direct oral anticoagulants
clinical practice
genome wide
gene expression
risk assessment
climate change
human health
clinical decision support
electronic health record