Large Cell Calcifying Sertoli Cell Tumour: A Contemporary Multi-Institutional Case Series Highlighting the Diagnostic Utility of PRKAR1A Immunohistochemistry.

William J Anderson Jennifer B Gordetsky Muhammad T Idrees Khaleel I Al-ObaidyChia-Sui KaoKristine M CornejoSara E WobkerJohn C ChevilleSara O VargasChristopher D M FletcherMichelle S HirschAndres Martin Acosta

Published in: Histopathology (2021)

Overall, PRKAR1A loss is both sensitive (93%) and highly specific (97%) for the diagnosis of LCCSCT. PRKAR1A loss may aid its diagnosis, particularly in sporadic cases and those that are the first presentation of Carney complex.

Keyphrases

single cell
cell therapy
stem cells
late onset
mesenchymal stem cells
early onset