Overexpressing wild-type γ2 subunits rescued the seizure phenotype in Gabrg2+/Q390X Dravet syndrome mice.

Xuan HuangChengwen ZhouMengnan TianJing-Qiong KangWangzhen ShenKelienne VerdierAurea PimentaRobert L MacDonald

Published in: Epilepsia (2017)

Based on these results we suggest that seizures in a genetic epilepsy syndrome caused by epilepsy mutant γ2(Q390X) subunits with dominant negative effects could be rescued potentially by overexpression of wild-type γ2 subunits.

Keyphrases

wild type
temporal lobe epilepsy
case report
cell proliferation
genome wide
type diabetes
copy number
metabolic syndrome
dna methylation
adipose tissue
insulin resistance