Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing.

Jennifer M GrantsChristina MayJosh BridgersShujun HuangSierra GillisBarbara MeissnerMerrill BoyleSusana Ben-NeriahStacy HungGerben DunsLaura HiltonAlina S GerrieMarco A MarraRobert KridelPeter J B SabatiniChristian SteidlDavid W ScottAly Karsan

Published in: Clinical chemistry (2024)

A targeted capture approach to IGHV SHM detection can be integrated into broader sequencing panels, allowing broad CLL prognostication in a single molecular assay.

Keyphrases

chronic lymphocytic leukemia
loop mediated isothermal amplification
cancer therapy
copy number
real time pcr
label free
single cell
gene expression
drug delivery
dna methylation
single molecule
genome wide
high throughput sequencing