Ambra1 deficiency impairs mitophagy in skeletal muscle.

Lisa GambarottoSamuele MettiMartina ChrisamCristina CerquaPatrizia SabatelliAndrea ArmaniCarlo ZanonMarianna SpizzotinSilvia CastagnaroFlavie StrappazzonPaolo GrumatiMatilde CesconPaola BraghettaEva TrevissonFrancesco CecconiPaolo Bonaldo

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Our study indicates that Ambra1 is critical for skeletal muscle mitophagy and for the proper maintenance of functional mitochondria.

Keyphrases

skeletal muscle
insulin resistance
nlrp inflammasome
replacement therapy
metabolic syndrome
endoplasmic reticulum
smoking cessation