A Mechanistic Absorption and Disposition Model of Ritonavir to Predict Exposure and Drug-Drug Interaction Potential of CYP3A4/5 and CYP2D6 Substrates.

Sumit AroraAmita PansariPeter J KilfordMasoud JameiDavid B TurnerIain Gardner

Published in: European journal of drug metabolism and pharmacokinetics (2022)

The current model, which incorporates formulation characteristics and mechanistic disposition parameters, can be used to assess the DDI potential of CYP3A4/5 and CYP2D6 substrates administered with a twice-daily dose of 100 mg of ritonavir for 14 days.

Keyphrases

drug delivery
physical activity
antiretroviral therapy
human health
emergency department
adverse drug
drug induced
electronic health record