Smooth muscle cell fate decisions decipher a high-resolution heterogeneity within atherosclerosis molecular subtypes.

Ge ZhangZaoqu LiuJinhai DengLong LiuYu LiSiyuan WengChunguang GuoZhaokai ZhouLi ZhangXiaofang WangGangqiong LiuJiacheng GuoJing BaiYunzhe WangYouyou DuTao-Sheng LiJun-Nan TangJinying Zhang

Published in: Journal of translational medicine (2022)

This study uncovered atherosclerosis complex cellular heterogeneity and a differentiated hierarchy of cell populations underlying SMC. The novel high-resolution stratification system could improve clinical outcomes and facilitate individualized management.

Keyphrases

high resolution
smooth muscle
single cell
cell fate
cardiovascular disease
mass spectrometry
cell therapy
tandem mass spectrometry
stem cells
high speed
liquid chromatography