Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age.

Tyler Reed BellJeremy A ElmanAsad BeckChristine Fennema-NotestineDaniel E GustavsonDonald J HaglerAmy J JackMichael J LyonsOlivia K PuckettRosemary ToomeyCarol E FranzWilliam S Kremen

Published in: Journal of the International Neuropsychological Society : JINS (2022)

Lower rostral-middle LC integrity is associated with greater subjective cognitive decline. Although not explained by objective cognitive performance, such a relationship may explain increased AD risk in people with subjective cognitive decline as the LC is an important neural substrate important for higher order cognitive processing, attention, and arousal and one of the first sites of AD pathology.

Keyphrases

cognitive decline
mild cognitive impairment
sleep quality
simultaneous determination
working memory
mass spectrometry
liquid chromatography
solid phase extraction
amino acid
high resolution mass spectrometry
tandem mass spectrometry