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Developmental endothelial locus-1 promotes osteogenic differentiation and alveolar bone regeneration in experimental periodontitis with type 2 diabetes mellitus.

Qian MaYiyao HuHan LiYunchun KuangJie LiJinglin Song
Published in: Journal of periodontal research (2023)
In summary, we demonstrated that DEL-1 could promote osteogenic differentiation of hPDLSCs in high glucose and inflammation environment and rescue alveolar bone loss in experimental periodontitis with T2DM, which could provide a novel therapeutic target for periodontitis with T2DM.
Keyphrases
  • high glucose
  • bone loss
  • endothelial cells
  • bone regeneration
  • oxidative stress
  • mesenchymal stem cells
  • bone marrow
  • skeletal muscle
  • adipose tissue
  • metabolic syndrome
  • insulin resistance
  • genome wide association study