Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND.
Ali A Al-MubarakNiels Grote BeverborgVictor ZwartkruisColinda van DeutekomMartin H de BorstRon T GansevoortStephan J L BakkerDaan J TouwRudolf A de BoerPeter van der MeerMichiel RienstraNils BomerPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)
Selenium deficiency was associated with new-onset AFib in non-smoking participants. Interventional studies that investigate the effects of optimizing micronutrients status in a population at risk are needed to assess causality, especially in those with selenium deficiency. Micronutrients deficiencies (selenium, iron, and magnesium) have been associated with cardiovascular diseases and mitochondrial dysfunction in human cardiomyocytes. However, it is not known whether these deficiencies are associated with atrial fibrillation. To investigate this question, we measured all three micronutrients in 5452 apparently healthy individuals. After a mean follow-up of 6.2 years, there were 136 participants who developed atrial fibrillation. Participants with selenium deficiency had a significant increased risk to develop atrial fibrillation, as did the participants with two or more deficiencies.
Keyphrases
- atrial fibrillation
- catheter ablation
- oral anticoagulants
- left atrial
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- cardiovascular disease
- replacement therapy
- type diabetes
- emergency department
- mitral valve
- smoking cessation
- venous thromboembolism
- metabolic syndrome
- big data
- case control