Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.
Julia HinterdoblerSimin SchottHong JinAlmut MeesmannAnna-Lena SteinsiekAnna-Sophia ZimmermannJana WobstPhilipp MüllerCarina MauersbergerBaiba VilneAlexandra BaecklundChien-Sin ChenAldo MoggioQuinte BrasterMichael MolitorMarkus KraneWolfgang E KempfKarl-Heinz LadwigMichael HristovMaarten HulsmansIngo HilgendorfChristian WeberPhilip WenzelChristoph ScheiermannLars MaegdefesselOliver SoehnleinPeter LibbyMatthias NahrendorfHeribert SchunkertThorsten KesslerHendrik B SagerPublished in: European heart journal (2021)
Our data show that acute mental stress rapidly amplifies inflammatory leucocyte expansion inside mouse atherosclerotic lesions and promotes plaque vulnerability.