High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status.
Kim E KortekaasSaskia J SantegoetsZiena AbdulrahmanVanessa J van HamMarij van der TolIlina EhsanHelena C van DoornTjalling BosseMariëtte I E van PoelgeestSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2019)
This is the first study demonstrating an association between intraepithelial T cells and clinical outcome in VSCC. Our data suggest that abnormal p53 expressing VSCCs mostly are cold tumors whereas HPV-driven VSCCs are strongly T-cell infiltrated.