Potentially Life-Threatening Interaction between Opioids and Intrathecal Baclofen in Individuals with a Childhood-Onset Neurological Disorder: A Case Series and Review of the Literature.

Liza M M van DijkAnnelies van ZwolAnnemieke I BuizerLaura A van de PolK Mariam SlotSaskia N de WildtLaura A Bonouvrié

Published in: Neuropediatrics (2024)

Although the opioid-ITB interaction is incompletely understood, concomitant use may enhance the risk of symptoms of CNS-depressant overdose, which are potentially life-threatening. If concomitant use is desirable, we strongly recommend to closely monitor these patients to detect interaction symptoms early. Awareness and monitoring of the potential opioid-ITB interaction is essential to reduce the risk of severe complications.

Keyphrases

chronic pain
pain management
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
blood brain barrier
early onset
peritoneal dialysis
patient reported outcomes
young adults
sleep quality
human health
depressive symptoms