Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants: A Patient-Level Meta-Analysis From COMBINE AF.

Linda S B Johnson Alexander P Benz Ashkan Shoamanesh John William Eikelboom Michael D Ezekowitz Robert P Giugliano Lars Wallentin Christian T Ruff Renato Deláscio Lopes Sanjit S Jolly Richard P Whitlock Christopher B Granger Stuart J Connolly Jeffrey S Healey

Published in: Journal of the American Heart Association (2024)

-VASc score, and stroke history can identify patients with AF, who despite oral anticoagulation have a residual stroke/SE risk of 1.5% to 2.5% per year. Evaluation of additional stroke/SE prevention strategies in high-risk patients is warranted.

Keyphrases

atrial fibrillation
oral anticoagulants
systematic review
end stage renal disease
ejection fraction
newly diagnosed
cerebral ischemia
patient reported outcomes
brain injury
meta analyses