LncRNA DLEU2 regulates sirtuins and mitochondrial respiratory chain complex IV: a novel pathway in obesity and offspring's health.
Jian ZhangMatthew Krivacka KayMin Hi ParkSunitha MeruvuCatherine PowellMahua ChoudhuryPublished in: International journal of obesity (2005) (2022)
Our findings reveal for the first time that one lncRNA can regulate sirtuins and a specific mitochondrial complex. Furthermore, diet or maternal diet can modulate Dleu2 and its downstream regulators in offspring, suggesting a potential role of DLEU2 in metabolic disorders over one or more generations.
Keyphrases
- weight loss
- high fat diet
- oxidative stress
- physical activity
- long non coding rna
- insulin resistance
- healthcare
- public health
- metabolic syndrome
- type diabetes
- mental health
- long noncoding rna
- human health
- transcription factor
- weight gain
- single cell
- health information
- skeletal muscle
- risk assessment
- gene expression
- health promotion
- climate change
- body mass index
- preterm birth