Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.

Lorna J DanielsRachel S WallaceOlivia M NicholsonGenevieve A WilsonFiona J McDonaldPeter P JonesJ Chris BaldiRegis R LambertsJeffrey R Erickson

Published in: Cardiovascular diabetology (2018)

Our results indicate that CaMKIIδ plays a key role in modulating performance of the diabetic heart, and moreover, suggest a potential therapeutic role for CaMKII inhibitors in improving myocardial function during type 2 diabetes.

Keyphrases

diabetic rats
type diabetes
protein kinase
oxidative stress
left ventricular
heart failure
skeletal muscle
glycemic control
cardiovascular disease
signaling pathway
tyrosine kinase
insulin resistance
wound healing
single molecule
atrial fibrillation
smooth muscle
metabolic syndrome