Incidence and predictors of major adverse drug events among drug-resistant tuberculosis patients on second-line anti-tuberculosis treatment in Amhara regional state public hospitals; Ethiopia: a retrospective cohort study.
Mehari Woldemariam MeridLemma Derseh GezieGetahun Molla KassaAtalay Goshu MulunehTemesgen Yihunie AkaluMelaku Kindie YenitPublished in: BMC infectious diseases (2019)
The incidence rate of major adverse drug events in the early 6 months of treatment was higher than that of the subsequent months. Age above 25 years, base line anemia, and co-morbid conditions were independent predictors of adverse drug events. Thus, addressing significant predictors and strengthening continuous follow-ups are highly recommended in the study setting.
Keyphrases
- adverse drug
- drug resistant
- electronic health record
- emergency department
- end stage renal disease
- multidrug resistant
- drug induced
- chronic kidney disease
- healthcare
- risk factors
- newly diagnosed
- acinetobacter baumannii
- mycobacterium tuberculosis
- bariatric surgery
- prognostic factors
- peritoneal dialysis
- combination therapy
- patient reported outcomes