Synergistic properties of linezolid against Enterococcus spp. isolates: a systematic review from in vitro studies.
Roberta Maria AntonelloNiccolò RiccardiLaura SaderiGiovanni SotgiuPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2023)
Our study reported overall limited synergistic in vitro properties of linezolid with other antibiotics when tested against Enterococcus spp. The clinical choice of linezolid in combination with other antibiotics should be guided by reasoned empiric therapy in the suspicion of a polymicrobial infection or targeted therapy on microbiological results, rather than on an intended synergistic effect of the linezolid-based combination.