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Transmission of Rift Valley fever virus from European-breed lambs to Culex pipiens mosquitoes.

Rianka P M VloetChantal B F VogelsConstantianus J M KoenraadtGorben P PijlmanMartin EidenJose L GonzalesLucien J M van KeulenPaul J Wichgers SchreurJeroen Kortekaas
Published in: PLoS neglected tropical diseases (2017)
We here report the vector competence of Cx. pipiens mosquitoes from the Netherlands for RVFV. Both laboratory-reared mosquitoes and well as those hatched from field-collected eggs were found to be competent vectors. Moreover, RVFV was transmitted efficiently from indigenous lambs to mosquitoes, although the duration of host infectivity was found to be shorter than previously assumed. Interestingly, analysis of mosquito-exposed skin samples revealed previously unidentified target cells of the virus. Our findings underscore the value of including natural target species in vector competence experiments.
Keyphrases
  • aedes aegypti
  • zika virus
  • dengue virus
  • induced apoptosis
  • cell cycle arrest
  • single cell
  • signaling pathway
  • cell death