A positive TGF-β/miR-9 regulatory loop promotes the expansion and activity of tumour-initiating cells in breast cancer.

Yichen LiuYing ChenQiong ZhaoTianyuan XieChenxi XiangQianqian GuoWenzhou ZhangYi ZhouYin YuanYuxin ZhangTao XiXiaoman LiLufeng Zheng

Published in: British journal of pharmacology (2023)

These findings demonstrate that miR-9 is an oncogenic miRNA rather than a tumour-suppressor in breast cancer, calling for rectification of the model for this conserved and highly abundant miRNA.

Keyphrases

transcription factor
cell proliferation
long non coding rna
long noncoding rna
induced apoptosis
cell cycle arrest
transforming growth factor
endoplasmic reticulum stress
young adults
cell death