GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an amyotrophic lateral sclerosis mouse model.

Didio Alberto OrtizNuria PeregrínMiguel ValenciaRodrigo Vinueza-GavilanesElisa Marín-OrdovasRoberto FerreroMaría Jesús NicolásGloria González-AseguinolazaMontserrat ArrasateTomás Aragón

Published in: Translational neurodegeneration (2024)

Keyphrases

amyotrophic lateral sclerosis
mouse model
single cell
oxidative stress
rna seq
wild type
oxide nanoparticles