Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response.

Fabian Ruperti Isabelle Becher Anniek Stokkermans Ling Wang Nick Marschlich Clement Potel Emanuel Maus Frank Stein Bernhard Drotleff Klaske J Schippers Michael Nickel Robert Prevedel Jacob M Musser Mikhail M Savitski Detlev Arendt

Published in: bioRxiv : the preprint server for biology (2023)

Sponge deflation is driven by tension release in actomyosin stress fibers of epithelial pinacocytesAkt kinase/Nitric oxide/Protein kinase G/A regulate actomyosin relaxationAgitation-induced deflation coincides with an inflammatory stateThe sponge relaxant-inflammatory response is evolutionary related to similar responses in the vertebrate vascular system.

Keyphrases

inflammatory response
protein kinase
nitric oxide
lipopolysaccharide induced
lps induced
toll like receptor
high glucose
oxidative stress
diabetic rats
single cell
nitric oxide synthase
drug induced
genome wide
gene expression
endothelial cells