IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAPK, and NF-kB Signaling in Rabbit Osteoarthritis.

Mohammad Amjad HossainAravinthan AdithanMd Jahangir AlamSpandana Rajendra KopalliBumseok KimChang-Won KangKi-Chul HwangJong-Hoon Kim

Published in: Journal of inflammation research (2021)

Our results indicate a protective effect of IGF-1 against OA pathogenesis by inhibition of NF-κB signaling via regulation of the MAPK and PI3K/Akt signaling pathways and prevention of apoptosis by suppression of ROS production.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
cell death
epithelial mesenchymal transition
induced apoptosis
knee osteoarthritis
oxidative stress
rheumatoid arthritis
endoplasmic reticulum stress
dna damage
reactive oxygen species
immune response
toll like receptor