Targeted NGS Molecular Profiling and Its Clinical Application in Adrenocortical Cancer.

Francesca CioppiGiulia CantiniTonino ErcolinoMassimiliano ChettaLorenzo ZanattaGabriella NesiMassimo MannelliMario MaggiLetizia Canu Michaela Luconi

Published in: European journal of endocrinology (2024)

A simplified targeted-NGS approach seems the best routinely applicable first step towards somatic genetic characterisation of ACC for prognostic assessment. This approach proved to be particularly promising in low-stage cases, suggesting the need for more stringent surveillance and personalised treatment.

Keyphrases

cancer therapy
papillary thyroid
copy number
public health
genome wide
single cell
squamous cell carcinoma
gene expression
drug delivery
young adults
lymph node metastasis
childhood cancer
smoking cessation