Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression.
Emilio PortaccioMatteo BettiErmelinda De MeoIlaria AddazioLuisa PastòLorenzo RazzoliniRocco TotaroDaniele SpitaleriAlessandra LugaresiEleonora CoccoMarco OnofrjFranco Di PalmaFrancesco PattiDavide MaimonePaola ValentinoValentina Torri ClericiAlessandra ProttiDiana FerraroGiacomo LusGiorgia Teresa ManiscalcoVincenzo Brescia MorraGiuseppe SalemiFranco GranellaIlaria PesciRoberto BergamaschiUmberto AgugliaMarika VianelloMarta SimoneVito LeporePietro IaffaldanoGiancarlo ComiMassimo FilippiMaria TrojanoMaria Pia Amatonull nullPublished in: Journal of neurology (2024)
In this real-world relapsing-onset MS cohort, PIRA was the main driver of disability accumulation and was associated with higher disability in the long term. Sustained PIRA was linked to transition to SP and could represent a more accurate PIRA definition and a criterion to mark the putative onset of the progressive phase.